Successful Natural Alternatives to Prostate Cancer Treatment

[This transcript is of a seminar that Dr. Ben Pfeifer gave at the Complementary & Natural Healthcare Expo at ExCel in London on 7th October 2007. The audience was a mix of the general public, alternative and complementary healthcare practitioners, and medical doctors. Dr. Pfeifer kindly gave us permission to reproduce his copyrighted lecture materials.]

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Good morning everyone,

Some of the slides do not work with the English laptops… they come from Swizerland… they didn't like the English laptop.

Anyway, I was asked to talk about some treatment methods for prostate cancer. I wanted to tell you where I come from. This is Lake Lucerne which is almost 40 miles long spanning from Lucerne all the way to Brunnen where the clinic is.

At the Eastern most end of the lake there is our integrative centre of oncology. This is an old hotel that was re-done inside and is a very nice environment for patients from all around the world who come to see us.

Prostate cancer — this is our subject today. In your country there is about 36,000 new cases every day… excuse me, every year. [Laughter] That would be a big change if it were every day! You don't have that many men in your country! But the sad story is that 11,000 of those men will die every year due to that cancer. What do we know about this cancer's development?

Well, it all starts with one cell and that cell could be there for 3-4 years without doing anything, sometimes even longer.

Once it transforms it stops following the rules, it does not die as it is supposed to. It does not follow apoptosis. And it engages in faster cell division, uncontrolled cell division. And often it also grows in dependence of testosterone levels — the male hormone levels. When cancer cells then clump together they form this sort of small tumour that can even leave the border of the tissue that they are starting to grow in. They can get access to vessels like in this case and spread. And they can get into lymphatic vessels and blood vessels, going to other organs in our body.

What does that mean if someone has the diagnosis with regards to survival?

You see here the curve of survivors on the left, and here you see years. And four curves. For the man that only has the cancer cells in the prostate, he is in stage one or two and survival can be very very long. We know today that most of the men in these two groups — I and II — will live five years without problems; many of them live ten years; some of them live fifteen years, with these cancers in stage I and II.

But once the cancer has gone out of the gland and spread into the body the story changes dramatically, and that is depicted here in this lower graph. You see that only 10 to 15% will see 5 years.

What are the therapy options for this cancer? If the cancer, as shown here, is only in the prostate and it's a young patient, then radical prostatectomy will be done. That means the surgeon or urologist will take the whole gland out, hopefully the problem is resolved.

When the cancer is going out of the prostate as shown here towards in the bladder neck or going out of the side leaving the capsule, the story changes. The chance of having metastases when this happens is in the high 80% even though we can not find it when the diagnosis is made. But patient will see the symptoms and the metastases coming within years.

When the cancer has gone out of the prostate and is somewhere else, hormonal therapy is done. That means for most of the men, castration — meaning depriving them of their normal male hormones. But we all know this only works for 2 years, 3 years with this hormonal therapy and then the patient enter a stage of the disease which is called hormone refractory disease. All of a sudden, the withdrawal of the male hormone is not helpful any more, is not effective any more, and what then can be done ? Some say for the elderly, aged 75+ we should not do anything — we should just watch. We call it nicely watchful waiting, don't do anything. Because some of the cancers really are not so aggressive, and men who have these non-aggressive cancers at a high age will die with the cancer not because of the cancer.

Others say we need to do chemotherapy in particular for younger men if they have reached hormone refractory stage. But we say before we start chemotherapy because of its many side-effects on patients, we should do a different route. And we have developed a complementary treatment regimen that we want to talk to you about today.

This non-toxic treatment regimen has 6 components, 4 of which we have presented years ago now — 7 years ago now. These are the first 4 that you see here — Prostasol, Curmin Complex, BioBran and Imupros. And lately we have added a substance known as TMAZ which I will explain to you and a certain diet as we have seen we can improve results even more with the addition of these two measures.

I will show you a bit about Prostasol quickly. We know it has an extract mixture of 9 medicinal plants, we know it inhibits cancer growth and reduces PSA and it can reduce pain in those men who have bone metastases from this cancer. What the good thing is about Prostisol is that it was shown from studies, and that study was also done even in your country at a study at St Bart's hospital by Professor Oliver, it was shown that it can even be efficacious in men who are hormonal-refractive and do not have any hormonal treatment options left for them.

Here we see what it does in the laboratory. It clearly inhibits cancer cells that grow in the Petri dish. And that inhibition of growth is happening in a dose dependent fashion that means the more you put in the Petri dish the less cancer cells grow. But it also down-regulates a gene in the prostate cancer cells which is responsible for PSA expression, that gene is called androgen receptor. It is this protein on the cancer cell that testosterone docks onto and tells the cell to start dividing. Then we have seen Prostasol can sensitive prostate cancer cells to heat and radiation. And that is a very interesting finding because all of the men I sent to radiation therapy will have adjunct treatment with Prostasol as we know it makes the cancer cells more sensitive to radiation damage.

The second compound that we use is Curcumin which most know it comes from the plant known as turmeric root — see on the picture. And the root part is taken and ground up to make a yellowish powder which the Indian cuisine has in almost all their dishes. But we are not out for the powder itself, but we wish to extract what is known as curcuminoid A and B from which we can get a very active substance in terms of prostate cancer.

If we now put some black pepper extract into the curcuminoids then we have a 1000-fold reabsorption from the gut — that is very important. If you take curcumin that makes the rice yellow or meat taste better, you will not absorb curcuminoids through your gut, if you eat it with black pepper extract, a 1000-fold increase. And the curcumin has health developments, if you look at the slide: It inhibits cancer development, it suppresses cancer growth and has a lot of anti-inflammatory effect. In fact most of my patients with rheumatoid arthritis come for that and curcumin taken will reduce inflammation in this disease.

Here you will see curcumin's effect on patients that were hormonal refractory, curcumin alone will decrease PSA and this is the same with hormone naïve patients, if 3g taken a day. It should be taken with food to stop stomach upset.

The next compound is BioBran- a substance that has been shown for a long time that it improves immune system function. In particular the NK cells — our NK cells are the front line soldiers in the fight against cancer, natural killers cells they are also called. And these NK cells they are stimulated by this substance which is called Arabinoxylan, a combination of a sugar arabinose and xylose. It is not sweet at all and has no negative effects of glucose or other sugars. Instead it stimulates immune system tremendously. And how it does that I will show you in the next couple of slides.

If you give volunteers BioBran and you check their NK Cell activity over 2 to 3 weeks you see this curve. You will increase from 60—70% if you give 2g a day. If you give 3g a day you can do this in their function and their numbers by up to 200%. But what does this mean? Does this also happen in prostate cancer patients? Yes it does.

Here you see 15 patients with metastatic disease and the end of their rope eating only 2g of BioBran a day and you will see that their NK Cell activity measured here is increasing by close to 150%. Does that mean they are getting better? In many patients — yes.

If you look at this graph here, you will see that NK cell activity is depressed in most of the cancers — lung cancer, ovarian cancer, breast caner, prostate cancer. In end stage disease compared to healthy NK cell function you have only about 25-30% left of these major soldiers in your fight against cancer. And that is a target for BioBran and these cells need to be increased. That this really means something for patients is shown in this graph.

This contains a lot of numbers, all I want to show you is that the Japanese looked at cancer patients after conventional treatment — surgery and chemotherapy — and all they were interested in was showing what happens when they take Biobran after two years — the Biobran Group — and what happened to people who did not take it. And you see here clearly that two year survival in these patients Stage III and IV (end stage disease) you have 54% living and only 33% living in the control group. That is why the Japanese Ministry of Health has done more studies with this showing that effecting good NK Cell function by taking BioBran can save lives.

The last compound in this initial protocol is Imupros — a mixture of vitamins and minerals and some what's called vital nutrients like genistein and lycopene.

We give that to our patients regularly who still have their prostate gland to keep rest of the tissue in the gland as healthy as possible. And we have seen that Imupros can not only facilitate prostate health but is also helping prostate cancer patients in regard to their treatment effect, adding this for prostate cancer 2 to 3 times a day will make a difference for prognosis.

I will show you a couple of examples that I have shown in the past because they are very good examples to show what this can do. This was a patient who was diagnosed when he was 70 years old with metastatic prostate cancer and whose PSA was very high at this time – close to 1000 and had multiple metastases in lungs and bones. And a lot of pain that made his life miserable.

He had been through all the traditional therapies and he did not want any more. He did not want chemotherapy, because his brother died with the same disease with chemotherapy. So he started on the protocol with an excellent result. His PSA declined to non measurable levels (below 0.01) within 9 months.

And his bone lesions were not visible any more after 1 year; his lung lesions were not visible any more after 2 years and his quality of life was back. I show you his PSA curve that you see here. You see his lung picture before the treatment with very small nodules of lung metastases everywhere where those arrows are. Then after 10 months of treatment his radiologist says, well those 3 arrows might be cancer but we do not know — it could also be scarring.

This is his bone scan, where we give patients Technetium radioactive isotope that homes in on to the prostate cancer areas in the bone and makes the film black. You see here where those arrows are these are all metastasis in the spine, one is very bad looking in the first vertebra. If that breaks you are paralysed up to the upper lip. And can not breathe anymore on your own. Then there is a large metastases down here and all these metastases, not in all men but in many men, cause a lot of pain, a lot of discomfort. In this gentleman it did.

This is 11 months later: the radiologist tells us he can not see the metastases anymore. I'm very cautious in saying they are gone — no — but we cannot see them and the patient is doing much better.

Here are the results for this man who started the treatment earlier in 2001 and here is still in the same position — PSA is still smaller than 0.1 and is active, visiting his son in the States two times a year, doing his yacht and very very happy.

Here is a second patient, a younger one who after the surgery — he had a radical prostatectomy — that means his prostate was taken out. But as with many cases almost 50% of radical operated men, their cancer comes back after a certain time. That means that gold standard surgery really does not have the characteristics of gold standard. Almost 50% come back.

This man was one of those and his PSA increased to almost 90 while receiving complete hormone blockade — he received the treatment that is given in that situation: castrating therapy.

And he had unclear abdominal pain and his CT scan showed there was what's called lymphadenopathy — cancer went into the lymph nodes and made them bigger. So that they can be seen on CT scanning — one of those was close to 5cm in diameter. Normally we do not usually consider lymph nodes to be suspicious when they are smaller than 1 cm in diameter. And this large lymph node compressed one of this man's urethras — the tubes that bring the urine down from the bladder. This leads to a condition known as hydronephrosis — the urine is backing up unto the kidneys destroying it in the long run. And there was a large pulmonary mass. This patient also refused chemotherapy and started on the protocol.

This is his PSA curve and you will see clearly how this comes down nicely within a year's time.

That is one of his CT scan pictures. This area here is a lymph node that is almost as big as the aorta, the big vessel around there. And after four months or so that had come down to less than half the size.

That is an unusual picture for a prostate cancer with lung metastases, but this was punctured actually. Histology was taken — that means it was proven that this was a prostate cancer lesion. After five months you cannot see it any more. So that was a very successful patient too.

This is the situation today after many many years for this man. Also a success.

Do I only have good cases? Of course not. Many disappointing cases. And with this protocol that gives hope to so many men that have gone through conventional treatment already, I still am often disappointed that it does not work as good as I hoped or not as long as I hoped. And for those men there is often nothing out there any more but turning back to chemotherapy, of which we know for this particular cancer that it does not prolong life for the men that have this cancer.

In any event, we did a clinical study that was sponsored by two private individuals in Switzerland looking at whether this protocol can really do something for patients. We had the same combination therapy — Prostasol, curcumin, Biobran — examined in 194 patients. We looked at PSA over a year's time, at CT scanning, at bone scanning, at MRI and quality of life. And the Prostasol, Curcumin and Imupros was provided by Med Pro in Holland — some of free of charge, I must say that. And the BioBran from Daiwa Pharmaceuticals manufactured in Japan, some of it also free of charge.

The patient number was 194 in that study and we saw them every month for 12 months. Here's what we found.

There is close to two-thirds of patients (60%) that were already hormonal refractory that had no other treatment left but chemotherapy or none, that had at least a 50% decline in PSA – that's a conventional medicine standard. 50% decline in PSA means response, so we had in these patients at end of their rope with regard to therapy a two-third response rate. This is astonishingly high. We saw a reduction in tumour volume, as I showed you in those two examples, and we saw an improvement in quality of life and we saw a reduction of pain. Now Prostasol is high in phytoestrogens and these most likely cause the side effects that are mentioned down here:

Some patients — 30-40% — experience breast nipple soreness. Some even see a bit of breast growth as it is in a young girl that just went through puberty. And we see some dyspepsia… most of the time a bit of soft stool at the beginning. And some patients even had to stop the protocol because of these side-effects. But nothing we know is free in life and if you intervene at some end, you get problems at another end and we have learnt that too.

But dispite the disappointing side-effects with some patients we have more than 6 years experience with more that 1200 patients and we can fairly say that this programme manages to improve general condition in two-thirds of the patients — PSA comes down and tumour related pain decreases.

Despite these encouraging results, I always ask myself, well, can I do more? It is not too bad what we have achieved here but can we do more for those patients? And I think there is more with these 2 things. One is called TMAZ which stands for Tribo Mechanically Activated Zeolite and the other is a special diet I want to discuss in a bit.

And now I pick up a bit in tempo as I don't have too much time.

But what is TMAZ? It's raw material is basically a stone with a chemical formula of AL₂Si0₄ — aluminium silicate. What we have seen is with this stone if you grind it down to nano-particle size, the stone is causing a multitude of biological effects that the stone when you have it in bigger size does not cause.

The nano-particle sized zeolite is a very strong cation-exchanger. It has antioxidative efficacy, it's detoxifying and it is immune system modulating.

The other people that can make micronised or nano-particle size zeolite today are a small group of scientists in Croatia with a world patented technology that I'll show you in the next slide.

This is a machine that has 2 counter-clockwise rotating discs of a special metal covered with diamonds. And what they do if you pour in a bit of that already-ground down stone in the machine, then the 2 rotating blades cause high speed collision of the particles and when that happens, the particles get smaller and smaller and smalller, and in the end the chemical structure of this micro porous stone changes. And when that happens this stone is now ready to cause biological effects.

If you eat you can not absorb ammonia, you can not absorb mercury you can absorb other heavy metals. That has been proven because it is a registered drug in Europe. You can even order through the pharmacy as a detoxifier. It has approval in Germany and Holland and other European countries. I am not sure whether England has specially approved it, but due to reprocity laws in the European Community you could actually buy that through the pharmacy.

Here is what we know it can do in the human body. We can make the antioxidative power of vitamin C 1,000 times higher if we put them together. This has been proven in the lab as well. If we put it together with green tea, it becomes 1,400 times higher than the green tea bag. It is very strange what happens there but it is proven. It detoxifies, it takes heavy metals out of the system in particular mercury, ammonium and it is an immune system modulating substance.

Here is what we know here today it does to the immune system. It activates macrophages — these are cells that are first police guards in response to invaders, including tumour cells. It stimulates production of these cytokines, it stimulates CD4 cells, it stimulates B cells, dentritic cells and even NK cells — the very same cells that play a role in first line defense against cancer. Which we have seen can be stimulated really well with BioBran.

Here are some peer-reviewed publications to that extent: Immunostimulatory effect natural clinoptilolite (another word for that particular zeolite) and its antimetastatic ability. For those that are interested they can find this.

Here is another anti-cancer, anti-oxidative effects of micronised zeolite-clinoptilite in anti-ancer research and there is many many more.

This has been unknown for a long time despite having been published but the papers that come from an Eastern European country and are not looked upon with the same credit they would be looked upon if they were published by Americans. That is a sad truth.

Now the last pictures I want to see you concern the diet. Now, when I hear of diet, in my last book, I wrote 30 pages on diet, but at the end I could have written there is no special cancer diet. Because that is what all the various diets in the end lead me to believe. But here is something that needs credit that I want to discuss briefly with you.

Dr Coy is a colleague of mine at the Heidelberg Institute of Cancer Research — a very prestigious place in Germany and he was working there as a Molecular Biologist for a long time. And when he was first told me about an enzyme called transketalase like 1, I was bringing up my hands and saying I don't know much about biochemistry anymore. And when he showed me his idea of cancer patient diet, I said this is completely contrary to what we do at our clinic. We are a vegetarian clinic, and here you bring the meat and the cake and the sweet marmalade. But he said to me look at it first, try it out and tell me what you think. Because we claim that our Tavarlin Diet nutritions inhibit transkelase TKTL1 metabolism and supress tomour growth.

And he showed me a couple of pictures of patients with glyoma — bad brain tumors — that were on the diet for half a year and the brain tumors actually vanished. I have not seen that on a diet before. Maybe the Budwig diet — which some of you may have heard before — an old lady who died in Germany aged 92. A lipid researcher, nominated for Nobel Prize 4 times, a diet which consisted of just cottage cheese and flax seed oil and people lived off just this for years.

And BBC went to visit her clinic and look at her patient records and could find people living 25 years after they'd been declared dead by conventional oncologists with cancers that were clearly a death sentence. So something of old lady Budwig's diet worked — and Coy's diet is the same in that no glucose and no high glycaemic index nutrition that can easily be converted into glucose in the body is used. Rather good oils, good fats and good protein.

Let's talk at TKTL1. When I saw that I didn't know where to put it. Now this slide here shows you very much out of my biochemistry book I looked up. On the lefthand side you see what our glucose metabolism is doing. Glucose goes in here and at the end normally CO₂ and water have to come out and a lot of energy has to be produced by 1 mol of glucose. But somewhere in there, you see TKTL1 — it is an enzyme that is directing glucose in various ways for metabolism. Now that doesn't tell us much yet, but look at the next couple of slides:

Normally all of our cells when they see glucose can do this. They take 1 mol of glucose and through various steps — one is called the Embden-Meyerhof-Parnas [EMP] pathway, one is called the citrate cycle — and in the end in the mitochondria, glucose is burned to CO₂ and water, and 2 mols of ATP come out and 34 mols of ATP more out of the mitochondria. So from 1 mol of glucose we create 36 mol of ATP. ATP is adenose triphosphate — the energy storage molecule in our body, without it we wouldn't exist.

Now this is the situation for all normal cells, when they have, see and breathe oxygen. Now see the situation when a guy who is running a 100 metre sprint, he can only breathe two to three times in that 100 metres. So the best guys in the world do all that work — the best guys in the world — from A-B, 100 metres, anaerobically. Without oxygen. Muscle cells are the only cells in our body that can do that for a long time. But then at the end when he reaches the finish line, he goes [pants heavily] and catches up, brings in the oxygen to get rid of 1 molecule of lactate. And you see by doing so, using glycolsis you can only make a small amount of energy only 2 mol of ATP, if you don't burn the oxygen down to CO2 and water, you just ferment sugar. And that energy deficit is the biggest problem when you have cancer because cancer does the same thing.

Whether oxygen is there or not. It uses only glycolosis. That was found out by a German professor in the 1930s — Professor Otto Warburg — and he won a Nobel prize for that. But we have forgotten about that theory for a long time. When chemotherapy came along no one interested in the metabolism of cancer cells per se any more, because there is no money in a diet; there is no money in reducing glucose in the nutrition to treat cancer. Chemotherapy was taking over for decades in our thinking.

But Warberg said in 1934 that cancer cells do use glycolysis — fermentation to make energy. And if they can only make 2 mol of ATP out of 1 mol of glucose, you can imagine that to grow they must pull in glucose, glucose, glucose. And if we give them glucose in our nutrition — that's Coy's idea — we maintain their energy needs. So here's what the cancer cell is doing.

The cancer cell switches off the Embden-Meyerhof pathway; it switches off the citrate cycle; it switches off mitochondrial energy production. And it makes, out of 1 mol of glucose, only 2 mols of ATP and a lot of lactate.

Now lactate we also make when we exhaust ourselves on the treadmill, it makes our muscles sore that is where the muscle soreness comes from after a work out. Lactate has one big draw back. The cancer cells' lactate can not be easily reconverted — other lactate from muscles yes — but the cancer cells' lactate — not. It's left and right drawing lactate molecules they call it in biochemistry. But here important for cancer patients, lactate will make the surrounding tissue acidic, it will break down borders, it will allow the cancer cells to spread — to grow and leave the group of cancer cells to which it belongs and go and create mestastases.

And you see what the high lactate is doing, it is causing invasion, or facilitating the invasion, of metastases, it is causing angiogenesis. It tells your body to make more blood vessels to feed the cancer that is growing. And many more. And here again you see this very same transketalase enzyme that we started with.

The Pentose Phosphate pathway — the PPP — that is switched on dramatically in cancer cells is switched on because of this enzyme, the TKTL1. And that is what Coy found and in a couple of years I am very positive he will be a multi-multi-millionaire because that enzyme is the only enzyme in history that could be patented. And Coy has the world-wide patent on that. He of course is being approached by many pharmaceuticals to sell the patent. Why is that so important? Imagine: he finds something so important to switch off the enzyme. The pathway — the Pentose Phosphate pathway — that is bringing the cancer cell into glucose metabolism over-drive, is then blocked and a substance that will switch off that enzyme is worth billions. And I know and I am buying stock now if they come out. [Audience laughs].

Look at the main Western lifestyle — carbohydrates carbohydrates carbohydrates — this is our food. If you look back 10,000 years what were we eating? Berries- maybe. Honey, once in a while when we caught bees. But while we were hunting the only thing we ate was meat. Grains when they came, they ruined our lives. As we started to eat easily digestible carbohydrates. If you look back in the diet history, in the 1900s the per capita sugar use in the Western European countries was 2.7 kilo per capita. That data exists in Germany. In 2000, the per capita use of glucose or sugar was 112 kilo. From 2 to 100 that is crazy, we are not made for that, we are not made for metabolising sugar only. That is where our diseases come from, I strongly believe Coy has very good thoughts.

We are decreasing our physical activity, we were hunting earlier, now we are sitting eating our "crunchies" at home, we are eating our sugary meals at home. That is where many of the chronic diseases come from. And this type of lifestyle, this type of food, promotes TKTL1 fermentation in cancer cells.

Now here is how the loop is closing. The Tavarlin nutrition that looks like normal nutrition avoids all easily digested carbohydrates. So the noodles that you saw our actually protein and not carbohydrates. The bread, the pasta is protein, not carbohydrate. So this diet tries to switch on mitochondria again and switch off the glucose metabolism overdrive of cancer cells, thereby suppressing cancer growth.

And here are the publications that might of interest: The British Journal of Cancer- 'The Expression of TKTL1 predicts colon and urethral cancer survival'. That means that patients who have a high activity of that enzyme, meaning a high glucose overdrive in the cancer cells will have a much worse prognosis, and die earlier. Patients that have a low TKTL1 activity will live longer. That could be shown and is published here in this. And there is plenty more literature for those that want to see that. If you type in TKTL1 into Google, you get a myriad of interesting articles.

We are running out of time.. Please allow me some thoughts… disturbing thoughts.

We are running out of time.. Please allow me some thoughts… disturbing thoughts. Deaths due to medical errors. When we started looking into that in 2000 in the States. Around 100,000 Americans die yearly in hospital due to medical error. That means the physician did something wrong, the nurse did something wrong, or drug interactions caused an accidental death.

Then a couple of years later that number was corrected and it was said death due to medical errors is the fourth leading death in the United States. So that's not very enticing to go to the hospital. The American Medical Association — the AMA — reports that approximately 100,000-200,000 die every year in US hospitals due to medical errors. I do not know how many patients that is in Switzerland or in your country — these numbers are not available. But this certainly does not cause any increase in my confidence.

To err is human we say, and to a certain extent that can happen to all of us and forgiveness is something important in our medical practice as well. And it causes a lot of frustration when that happens, and I want to show you how frustrated some people can get in my last little picture that might take away from that seriousness of the last couple of slides.

[Slide is video: shows a double glazing advert showing frustration of patients]

I wish very often we can open up the yellow pages for our patients but often I don't find anything there either. Thank you for our attention.

[Audience applause]

Is there any questions I would be happy to answer them here or downstairs at the stand. I will be a couple of minutes down there, or a couple of half-hours down there, and answer some questions.

Question from the audience: Do you use the protocol with conventional medicine?

Yes. we do very often Madame. In particular when patients are on LHRH antagonist, on the injection Zoladex/Lupron we are adding this when we see the Lupron is not holding the disease — the PSA is increasing while they are getting their injection — then we start on that one. It is completely compatible.

Question from the audience: A lot of oncologists are very worried about people using supplements during chemo. What is your opinion?

We are combining it generally with Taxotere or Mitomycin. There is some real concerns if you look at the chemotherapy that is acting through its generation of free radicals and now you give something that is putting free radicals down. Then you could make a point and say: well, on the one had we want free radicals to destroy cancer cells, on the other hand you should not take a food supplement that is bringing that free radical concentration down then we do not get the full effect of the chemotherapy. Depends very much on where chemotherapy acts. Taxanes, for example Taxotere and Mitomycin which are often used for prostate cancer have a different mode of action and we are not concerned about this. With this program added to Taxotere we have very good response rate and very good experiences. No quesiton that oncologists would also see that it has advantages because the free radical issue is not a question here.

Question from the audience: What about Tamoxifen?

Tamoxifen is a substance that is often used in post-menopausal breast cancer patients as an anti-oestrogen. And for breast cancer — I will talk about it in the afternoon a bit — we use a slightly different protocol here. We are not using phytoestrogens, but we use another substance called Indole-3-Carbinol. The substance Indole-3-Carbinole combined with Tamoxifen is no problem — I have many patients taking that. Although we know that Indole-3-Carbinole is actually having a similar effect as Tamoxifen — to a greater extent with less side-effects. So some of my patients overlap [take both] and then go off the Tamoxifen and continue with the Indole-3-Carbinole.

Question from the audience: Does the protocol have any value for patients with hormonal refractory cancer?

The protocol has meaning in that stage as well if you are concerned that the hormonal refractory stage should be avoided. I am a firm believer that we can avoid it by using what is called intermittent therapy — that means coming off for a while, coming back on, coming off and coming back on [hormonal therapies]. During that time in the off period, I often give a scaled-down version of that protocol to get a longer run in the off time. We are using this intermittent protocol a year-long complete hormone blockade therapy (castration therapy for year) then we come off totally. We take out the anti-androgen and take out the LHRL antagonist —the injection. The man is starting to have a recovery of the testicular function. Testosterone is coming back slowly, men feel much better during that time. And in order to give them a much longer run I use a very minute dose of the protocol. Perhaps one or two capsules of Prostasol (whereas other men who get this as a straight treatment get 6-8 capsules a day).

Question from the audience: Can it be used with aggressive prostate cancer with a high Gleason score?

Yes that is possible depending on three parameters that we measure often. That is PSA, which everyone measures, but also NSE and Chromogranin A — two parameters that are helpful in judging whether the cancer is becoming irresponsive to the treatment, number one, and also judging whether the cancer is turning towards a different variety that is not responding any more to hormonal manipulation. So if we measure those three parameters then I would feel safer in guiding even a longer period for a man with high grade Gleason — meaning 8 or 9.

Question from the audience: How can we get more information regarding the Budwig diet?

25 men were visited and there is information on that. If you go on Google and type in the name of the lady, then you see in the English sites her life's work. Her name is [spells it out] BUDWIG.

Question from the audience: Does Prostasol work on an enlarged prostate?

Actually we are started using it, but we were disappointed. We know in the beginning it does work — if somebody has a problem with urinary obstruction and urgency, with small volumes and high remaining urine after voiding —these are the criteria for benign prostatic hyperplasia [BPH]. We get an initial response rate because the protocol scales down the division rate in the prostate for a while, even in the good/benign cells. But then the symptoms come back and we have not propagated it for this.

Question from the audience: If somebody is not able to come over to Switzerland to see you and spend time at the clinic, regarding the products that you have spoken about, is there something generic that people could begin with?

Yes. These products can be all had — they are not confined to our place at all. We have done the first attemps, walking attemps in this direction using those products in combination. I have seen good results and have improved on them over the years. But you can get these products here. You have people here in Great Britain — colleagues of mine — that have come to our place and have looked at the patient protocols. They can direct you in this country. No problem.

I think we should stop now — we are done. If there are more questions, please come down and ask me personally. I wish you a good afternoon and good lunch break.

[Ends….]